Neo-adjuvant Chemo and Immunotherapy in the Pre-operAtive Treatment of Locally Advanced CholangIOcarciNoma

This study tests chemotherapy and immunotherapy given before surgery in patients with locally advanced cholangiocarcinoma — a cancer of the bile ducts inside or near the liver that is currently considered too difficult to operate on immediately. **You may be eligible if...** - You are over 18 years old with a confirmed bile duct cancer diagnosis - Your cancer is locally advanced but has been assessed in a multidisciplinary team meeting - You have not yet received any cancer treatment - You are in good general health (ECOG 0 or 1) with adequate blood, liver, and kidney function - Your weight is over 30 kg **You may NOT be eligible if...** - Your cancer has spread to other parts of the body - You have serious heart, lung, or immune system problems - You have active hepatitis B, C, or HIV - You are pregnant or breastfeeding - You have had major surgery in the past 4 weeks Talk to your doctor to see if this trial is right for you.