Intraperitoneal FT536 in Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
Masonic Cancer Center, University of Minnesota
33 participants
Jul 11, 2024
INTERVENTIONAL
Conditions
Summary
This is a single center Phase I clinical trial of FT536 administered intraperitoneally (IP) 3 times a week for one week for the treatment of recurrent gynecologic cancers. A short course of outpatient lymphodepleting chemotherapy is given prior to the first dose of FT536 to promote adoptive transfer.
Eligibility
Plain Language Summary
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Interventions
FT536 is an allogeneic natural killer (NK)-cell immunotherapy produced from a clonal master humaninduced pluripotent stem cell (iPSC) line.
Fludarabine 25 mg/m2 IV given on day -5. Given consecutively with CY.
CY 300 mg/m2 IV given on day -4. Given consecutively with Fludarabine.
Locations(1)
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NCT06342986