RecruitingPhase 1Phase 2NCT06343311

T-Cell Therapy (EB103) in Adults With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)

An Open-Label, Dose Escalation, Multi-Center Phase I/II Clinical Trial of EB103 T-Cell Therapy in Adults With Relapsed/Refractory (R/R) B-Cell Non-Hodgkin's Lymphoma (NHL)


Sponsor

Estrella Biopharma, Inc.

Enrollment

21 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open-label, dose escalation, multi-center, Phase I/II clinical trial to assess the safety of an autologous T-cell therapy (EB103) and to determine the Recommended Phase II Dose (RP2D) in adult subjects (≥ 18 years of age) who have relapsed/refractory (R/R) B-cell NHL. The study will include a dose escalation phase followed by an expansion phase.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests EB103, a new T-cell therapy (a type of treatment that uses engineered immune cells to fight cancer), in adults with B-cell non-Hodgkin's lymphoma that has relapsed or stopped responding to prior treatments. **You may be eligible if...** - You are 18 or older with confirmed B-cell non-Hodgkin's lymphoma - Your cancer has relapsed or failed to respond after at least 2 lines of treatment (or 1 line for Burkitt, mantle cell, or precursor B-cell lymphoma) - You previously received an anti-CD20 antibody (like rituximab) and anthracycline-based chemotherapy - Your disease is PET-scan positive - Your organ function is adequate **You may NOT be eligible if...** - You have active brain involvement from lymphoma - You have active serious infections or uncontrolled autoimmune disease - You are pregnant or breastfeeding - Your organ function is too impaired to safely receive the therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALEB103

EB103 is an autologous T-cell therapy whereby a subject's own T cells are transduced with a lentiviral vector expressing the EB103 transgene.


Locations(2)

University of California, Davis

Sacramento, California, United States

Baylor Scott & White Research Institute, Texas Oncology

Dallas, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT06343311


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