RecruitingPhase 4NCT06344195

Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening

Valacyclovir Monotherapy in Pain Management of Acute Apical Abscesses After Performing Emergency Chamber Opening; A Randomized Clinical Trial


Sponsor

Dow University of Health Sciences

Enrollment

82 participants

Start Date

Mar 27, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is aimed to evaluate the efficacy of valacyclovir in reducing postoperative pain following emergency chamber opening for acute apical abscess . There will be 82 participants, (41 in each group) Group A will receive Valacyclovir Group B will receive standard treatment i.e. Naproxen Sodium. Pain level will be assessed by using Numeric rating scale for 6 days


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Patient Age ≥18 years old
  • Healthy patient American Society of Anesthesiologists (ASA) class l and ll.
  • Patients having clinical evidence of pulp necrosis and acute apical abscess with radiographic signs of periapical disease.
  • to 3 as Mild pain. 4 to 6 as moderate pain. 7 to 10 as severe pain.

Exclusion Criteria5

  • Patient currently on antibiotics or antivirals
  • Smokers
  • Unusual tooth anatomy or inaccurate diagnosis
  • Pregnant or nursing mothers
  • Patients allergic to valacyclovir

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Interventions

DRUGValacyclovir 500 mg

Valtrex 2g immediate dose followed by 500mg 2 times daily for 3 days along with the analgesic (SOS, if needed) for 6 days

DRUGNaproxen Sodium 550mg

550mg (as needed, SOS) for 6 days


Locations(1)

Dr. Yumna Shaheen Ali

Karachi, Sindh, Pakistan

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NCT06344195


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