RecruitingNCT06346158

Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia

Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia During Induction of General Anesthesia Based on Electroencephalographic Features: a Prospective Observational Study

Sponsor

Ciusss de L'Est de l'Île de Montréal

Enrollment

110 participants

Start Date

Apr 7, 2025

Study Type

OBSERVATIONAL

Conditions

Anesthesia

Summary

The goal of this observational study is to explore the variability of the concentration at the effect site (Ce) of propofol to reach deep anesthesia (DA) during induction of general anesthesia in adults. The investigators hypothesized that there is a great variability in this Ce that could be precisely explained by * Electroencephalographic (EEG) features available prior to induction of anesthesia * Cognitive performance * Patients characteristics Participants will undergo preoperative cognitive testing and awake EEG. Then, induction of general anesthesia will be performed using continuous infusion of propofol. The Ce at which Deep anesthesia is observed will be recorded.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Scheduled for any kind of surgery under general anesthesia.
Adults

Exclusion Criteria6

Inability to communicate in French or English,
Known allergy or intolerance or other medical condition that precludes the use of prescribed general anesthesia protocol for this study,
Patients requiring rapid sequence induction,
Anticipated or known difficult intubation patient,
Anticipated or known difficult ventilation patient,
Body mass index ≥ 35 kg.m-2.

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