RecruitingNot ApplicableNCT06348069

Pharmacy-based PrEP for Young Women Who Sell Sex in Zimbabwe


Sponsor

University of California, Berkeley

Enrollment

200 participants

Start Date

Mar 25, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Pharmacy-based PrEP for Young Women who Sell Sex in Zimbabwe is a cluster-randomized control trial and pilot study co-led by Dr. Euphemia Sibanda, Reader (Associate Professor) of Global Health and Epidemiology at Liverpool School of Tropical Medicine, UK and Research Director at the Centre for Sexual Health and HIV Research (CeSHHAR Zimbabwe) and Dr. Sandra McCoy, Professor of Epidemiology and Biostatistics at the University of California, Berkeley. The goal of the proposed study is to optimize, refine and pilot a pharmacy-based PrEP intervention for female sex workers (FSW) in Zimbabwe. Despite efforts to reach the most impacted and vulnerable populations with PrEP, retention rates, particularly among FSW in Africa, are very low. Relatively high levels of uptake indicate that FSW are interested in PrEP and ready to initiate it, but in most cases fewer than 50% of those who initiate return for medication refills by month 4. Pharmacy-based PrEP has the potential to address known barriers to PrEP retention among FSW such as stigma and access, and coupled with a small escalating incentive in the form of a gift card incentive, could also boost motivation for effective use of PrEP.


Eligibility

Min Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether offering HIV prevention medication (PrEP — pre-exposure prophylaxis) through pharmacies is a practical and effective option for young women in Zimbabwe who exchange sex for money or gifts. The goal is to make HIV prevention more accessible outside of traditional clinic settings. **You may be eligible if...** - You are 16 years old or older - You have exchanged sex for money or gifts in the past 6 months - You have tested HIV-negative at enrollment and do not have signs of recent HIV infection **You may NOT be eligible if...** - You test HIV-positive at enrollment - You have symptoms suggesting a recent acute HIV infection Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALPharmacy-based PrEP refill and gift voucher

The intervention arm of this study introduces the opportunity for a pharmacy-based PrEP refill system for sex workers, coupled with financial incentives to increase adherence. Participants receive PrEP medications from selected pharmacies, a strategy designed to improve PrEP access and enhance privacy/discretion. Additionally, participants in the intervention are awarded escalating gift card values for each successful refill collection at study pharmacies, aiming to incentivize continued PrEP use for effective HIV prevention. The intervention seeks to enhance convenience and motivate adherence through financial rewards.

BEHAVIORALControl (Standard of care)

For sex workers in the control group, PrEP refill pick-up will be available through CESHHAR's existing network of clinical sites. There is no gift card incentive and no pick-up at private pharmacies.


Locations(1)

CESHHAR Zimbabwe

Harare, Zimbabwe

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NCT06348069


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