Pilot Study of LED for PIE and PIH
The Therapeutic and Preventive Effects of Light-emitting Diodes (LEDs) Irradiation for Post-inflammatory Erythema and Hyperpigmentation: a Self-controlled
Yanjun Dan
10 participants
Apr 10, 2024
INTERVENTIONAL
Conditions
Summary
The aim of this study is to explore the effect of medical LEDs (830 nm and 590 nm) in the prevention and treatment of PIE and PIH.
Eligibility
Inclusion Criteria4
- Healthy Asians;
- years old;
- Fitzpatrick classification III-IV;
- Sign the informed consent form.
Exclusion Criteria7
- Have abnormal skin manifestations, such as pigment diseases, photosensitivity diseases and other allergic diseases;
- Those with a history of abnormal systemic diseases, such as heart disease, liver disease, kidney disease, tumors, and mental illness;
- Women who are preparing for pregnancy, pregnant or breastfeeding;
- Have used photosensitizing drugs within two weeks before inclusion in this study;
- Topical or systemic drugs may be used during this study;
- bad habits, such as smoking, drinking, etc.;
- Volunteers who have recently participated in other clinical trials;
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Interventions
308 nm LED light was utilized to induce an vivo PIE/PIH model on the thigh of subjects. The irradiation dose was 1.5 MED. Five circular experimental lesions measuring 1.5 × 1.5 cm were selected on the thighs, categorizing into five groups: control group, 830 nm LED treatment group, 590 nm LED treatment group, 830 nm LED prevention group and 590 nm LED prevention group. 830 nm LED and 590 nm LED were irradiated, respectively. For therapeutic irradiation, the PIH model was induced on D1, and 830 nm (60 J/cm2, 50 mW/cm2) and 590 nm LED (20 J/cm2, 20 mW/cm2) were irradiated on D0, D1, D3, D6 and D8, respectively. For preventive irradiation, 830 nm and 590 nm LED were irradiated on D0, D1, D3, D6 and D8, respectively, and the PIE/PIH model was induced on D9.
without any LED exposition
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06349447