RecruitingNot ApplicableNCT06349447

Pilot Study of LED for PIE and PIH

The Therapeutic and Preventive Effects of Light-emitting Diodes (LEDs) Irradiation for Post-inflammatory Erythema and Hyperpigmentation: a Self-controlled


Sponsor

Yanjun Dan

Enrollment

10 participants

Start Date

Apr 10, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this study is to explore the effect of medical LEDs (830 nm and 590 nm) in the prevention and treatment of PIE and PIH.


Eligibility

Min Age: 20 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study explores whether LED light therapy using two specific wavelengths (830 nm and 590 nm) can prevent or treat two common skin concerns: post-inflammatory erythema (redness left after a pimple) and post-inflammatory hyperpigmentation (dark spots left after skin inflammation). Researchers will create small, controlled skin reactions on the thigh and then apply LED light at different sessions to see how well it reduces redness and pigmentation. Healthy Asian adults aged 20–65 with Fitzpatrick skin types III or IV (medium to darker skin tones) who have no skin or systemic conditions are eligible. Participation involves attending multiple visits over about 10 days for light treatments and skin measurements, with no expected significant discomfort. This summary was generated by AI to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICELED

308 nm LED light was utilized to induce an vivo PIE/PIH model on the thigh of subjects. The irradiation dose was 1.5 MED. Five circular experimental lesions measuring 1.5 × 1.5 cm were selected on the thighs, categorizing into five groups: control group, 830 nm LED treatment group, 590 nm LED treatment group, 830 nm LED prevention group and 590 nm LED prevention group. 830 nm LED and 590 nm LED were irradiated, respectively. For therapeutic irradiation, the PIH model was induced on D1, and 830 nm (60 J/cm2, 50 mW/cm2) and 590 nm LED (20 J/cm2, 20 mW/cm2) were irradiated on D0, D1, D3, D6 and D8, respectively. For preventive irradiation, 830 nm and 590 nm LED were irradiated on D0, D1, D3, D6 and D8, respectively, and the PIE/PIH model was induced on D9.

OTHERwithout any LED exposition

without any LED exposition


Locations(1)

Huashan Hospital

Shanghai, China

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NCT06349447


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