RecruitingNot ApplicableNCT06350201

Machine Learning-based Classification of Symptom Clusters and Online CBT

Machine Learning-based Classification of Symptom Clusters and Matched Online Cognitive Behavior Intervention for Depression Symptom and Anxiety Symptom


Sponsor

Wuhan Mental Health Centre

Enrollment

380 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

To breakthrough the bottleneck identified, we will conduct a cross-sectional study to develop a symptom clustering model for depression and anxiety. A wide range of statistical methods as well as machine learning approaches were explored, and a cohesive hierarchical clustering algorithm will be used. After developing the model, a symptom-matched intervention program based on problem solving therapy will be formulated. We are supposed to examine whether its use for personalizing symptom-matched psychological treatment can lead to improved patient outcomes, compared with usual care. This project is expected to provide a new and precise method for the emotion management, which will provide a standardized intervention pathway combining screening with treatment for the management of depression symptom and anxiety symptom. A preciser intervention matched to individual symptoms may provide important insight in improving patient outcome as well as a standardized mood management pathway targeting to the early detection and intervention for community residents.


Eligibility

Min Age: 18 YearsMax Age: 64 Years

Plain Language Summary

Simplified for easier understanding

This study uses machine learning (a form of artificial intelligence) to categorize groups of anxiety and depression symptoms, and then tests whether an online cognitive behavioral therapy (CBT) program delivered digitally can help people in each symptom group. **You may be eligible if...** - You are between 18 and 64 years old - You score 10 or above on a standard depression questionnaire (PHQ-9) and/or 8 or above on a standard anxiety questionnaire (GAD-7) - You are not currently receiving any psychological therapy **You may NOT be eligible if...** - You are currently receiving psychological or mental health therapy - You have attempted suicide in the past 2 months or are currently at acute risk of self-harm - You have been diagnosed with bipolar disorder or psychosis - You have significant cognitive impairment - You have alcohol or drug dependence - You have a serious unstable medical illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALproblem solving therapy

Problem-solving therapy-based holistic emotion management interventions matched to individual symptoms

OTHERcontrol group

Routine psychological care and guidance on mood management


Locations(1)

Renmin Hospital of Wuhan University

Wuhan, China

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NCT06350201


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