RecruitingNCT06352970

Effects of Tuberculosis Infection on Development and Function of the Placenta

Effects of Tuberculosis Infection on Placental Development and Function


Sponsor

Lund University

Enrollment

500 participants

Start Date

Oct 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta. The main questions it aims to answer are: * Does TB infection affect the structure of the placenta? * Does TB infection affect the function of the placenta? Pregnant women attending delivery clinics in Addis Abeba, Ethiopia, will be enrolled and classified for TB infection using a blood-based test. We will compare the following outcomes between women with TB infection and women without TB infection: * Pathological lesions of the placenta * Gene and protein expression patterns linked to pregnancy-related disorders * Infant outcome at birth and at 6 weeks after birth


Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria3

  • Women admitted for delivery to study sites
  • Written informed consent
  • Age 18 years or greater

Exclusion Criteria2

  • Chronic comorbidities (other than TB, HIV or pregnancy-related disorder)
  • Twin pregnancy

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERTB infection

Outcomes will be compared with regard to result of interferon-gamma release assay test for TB infection


Locations(1)

Gandhi Memorial Hospital

Addis Ababa, Ethiopia

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06352970


Related Trials