Reduced Stent Strategy Versus Conventional Percutaneous Coronary Revascularization in Patients Presenting With STEMI
Reduced Stent Strategy Versus Conventional Percutaneous Coronary Revascularization in Patients Presenting With St-segment Elevation Myocardial Infarction (Copernican)
Jorge Sanz Sanchez
1,272 participants
Mar 11, 2024
INTERVENTIONAL
Conditions
Summary
The objective is to compare a reduced stent strategy based on drug-coated balloon (DCB) percutaneous coronary intervention (PCI) with conventional drug-eluting stent (DES) coronary revascularization in patients presenting with ST-segment myocardial infarction (STEMI). Randomization will be performed after successful culprit-lesion guidewire crossing and flow restoration. Random allocation in a 1:1 fashion to one of the following strategies: * Study group: reduced stent PCI strategy (DCB-based) * Control group: conventional PCI strategy (DES-based).
Eligibility
Inclusion Criteria1
- \- Patients presenting with STEMI and indication to undergo pPCI.
Exclusion Criteria11
- Life expectancy <1 year due 1 to non-cardiac disease.
- Inability to provide informed consent.
- Cardiogenic shock.
- Left ventricular ejection fraction <15%.
- Left main disease.
- Stent thrombosis
- Patients with prior bypass graft lesions requiring PCI (culprit or non culprit lesions).
- Patients with chronic total occlusions.
- Untreatable coronary disease.
- Non-identified culprit lesion.
- Known allergy to aspirin, ticagrelor, prasugrel, clopidogrel, paclitaxel or sirolimus.
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Interventions
Coronary percutaneous revascularization
Locations(15)
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NCT06353594