ClinicalTrialsFinder
RecruitingNot ApplicableNCT06355778

Adversity, Brain and Opioid Use Study

A Mechanistic Investigation of Risk Factors for Opioid Use Disorder: Examining Hippocampal-based Context-dependent Learning and Memory Associated With Adverse Childhood Experiences

Sponsor

University of Michigan

Enrollment

185 participants

Start Date

Jan 9, 2025

Study Type

INTERVENTIONAL

Summary

The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Inclusion Criteria12

  • Right handed
  • Able to give informed consent
  • Normal/corrected-to-normal vision and hearing
  • Diagnosis of OUD
  • Be actively receiving buprenorphine (BUP) for opioid agonist therapy
  • Be free from illicit substance use for at least 2 weeks
  • The study will allow stable dose (> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)
  • Taking BUP for chronic pain
  • No Substance Use Disorder (including OUD)
  • The study will allow stable dose (> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)
  • Not taking BUP
  • Free of any psychiatric or major medical conditions

Exclusion Criteria9

  • Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis)
  • Actively suicidal
  • Contraindication for MRI
  • Inability to tolerate small, enclosed spaces without anxiety
  • Life history of schizophrenia, bipolar disorder, learning disability, attention deficit disorder, or pervasive developmental disorder
  • Use of substances or prescription medications that could interfere with measures of interest (per protocol)
  • Unable to provide informed consent
  • Participants who have completed other studies in our lab involving learning and memory assessments with the same/similar tasks used here (HUM00230585, HUM00121812) will not be eligible to complete the current study, due to possible learning/practice effects
  • Unable to fit comfortably in the MRI scanner due to body size (typically men over 6 feet tall that weigh more than 250 lbs, men under 6 feet tall that weigh over 220 lbs, women over 5'11" tall that weigh more than 220 lbs, or women under 5'10" tall that weigh more than 200 lbs).

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERMagnetic Resonance Imaging (MRI)

Enrolled participants will have one MRI during the study on day 2 after having Day 1 visit. During the MRI the participants will complete various tasks.

BEHAVIORALComputer Tasks

Eligible participants will complete computer tasks (cognitive tasks, spatial navigation tasks, context dependent fear learning, etc.) at visit 1 and then during the MRI.

Locations(1)

University of Michigan

Ann Arbor, Michigan, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06355778