RecruitingNot ApplicableNCT06355895

Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies

The Effect of Liver Volume Variation on Stereotactic Body Radiation Therapy (SBRT) Planning and Delivery for Upper Abdominal Malignancies


Sponsor

University of Pittsburgh

Enrollment

17 participants

Start Date

May 16, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease. The presence of diurnal and fasting/fed variations in liver volume therefore carry substantial potential for introducing errors into estimates of dose-volume distribution within normal liver tissue, as well as affecting day-to-day setup fidelity and organ alignment for treatment. This prospective study will examine how diurnal and fast-fed variations in liver volume affect treatment planning for abdominal SBRT.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study examines how the size of the liver changes between planning scans and actual radiation treatment sessions for patients receiving stereotactic body radiotherapy (SBRT) — a highly precise form of radiation — for tumors in the upper abdomen. Understanding liver volume changes helps doctors ensure radiation is delivered accurately. **You may be eligible if...** - You have a primary cancer of the pancreas, bile duct, or liver — or metastases in the liver, adrenal gland, or upper abdominal lymph nodes - You are planned to undergo SBRT (stereotactic body radiation therapy) **You may NOT be eligible if...** - You have previously received radiation therapy to the liver - You have a contraindication to IV contrast dye (such as kidney disease or contrast allergy that cannot be managed) - You are pregnant or breastfeeding, or cannot use adequate contraception during radiation - You are unable to fast before scans Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTStandardized high-carbohydrate meal

8 ounces of Ensure® nutritional protein shake or a similar meal


Locations(1)

UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, United States

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NCT06355895