RecruitingPhase 3NCT06361238

Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery

Perioperative Application of Liraglutide for the Prevention of Postoperative Delirium Among Elderly Patients with Type 2 Diabetes Undergoing Cardiac Surgery: a Single-Center Randomized Controlled Study


Sponsor

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Enrollment

260 participants

Start Date

Nov 19, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to clarify the preventive effect of perioperative liraglutide application on postoperative delirium in elderly patients with Type 2 diabetes undergoing cardiac surgery.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether liraglutide — a diabetes medication that also has protective effects on the brain — can prevent delirium (sudden confusion and disorientation) in older diabetic patients after heart surgery. Delirium is a common and dangerous complication following cardiac surgery, especially in the elderly. **You may be eligible if...** - You are 60 or older - You have Type 2 diabetes - You are scheduled for planned (elective) heart surgery **You may NOT be eligible if...** - You have a history of neurological or psychiatric conditions (e.g., epilepsy, Parkinson's disease, severe dementia, schizophrenia) - You have Type 1 diabetes - You have a history of pancreatitis (inflammation of the pancreas) - You have severe heart failure (NYHA Class IV) - You have severe liver or kidney disease requiring dialysis - You have difficulties with communication (severe hearing, vision, or speech problems) - Your blood sugar levels are difficult to control in the normal range during screening Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLiraglutide injection

Subcutaneous injection of liraglutide: 0.6 mg administered the day before surgery, 1.8 mg administered post-anesthesia induction on the day of surgery, followed by 0.6 mg daily for the first three postoperative days.

DRUGPlacebo injection

Subcutaneous injection of Placebo: the same volume as liraglutide administrated at the corresponding times.


Locations(1)

Wenxue liu

Nanjing, Jiangsu, China

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NCT06361238


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