RecruitingPhase 4NCT06365541

The Efficacy and Safety of Dapagliflozin in Improving Heart Failure in Dialysis Patients

Exploring the Efficacy and Safety of Dapagliflozin in Improving Heart Failure in Dialysis Patients: an Open, Prospective, and Self-controlled Study


Sponsor

The People's Hospital of Gaozhou

Enrollment

40 participants

Start Date

Mar 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Dialysis patients have a higher incidence of cardiovascular events and require more effective measures to delay the progression of heart failure. Many studies have shown that dapagliflozin has cardioprotective effect, but most studies focus on non-dialysis patients with eGFR more than 20ml/min/1.73m2. However, the data on patients with eGFR less than 20ml/min/1.73m2 or dialysis patients, especially peritoneal dialysis patients, is less. Exploring the efficacy and safety of Dapagliflozin in improving heart failure in dialysis patients is of great clinical significance.


Eligibility

Min Age: 20 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a diabetes medication called dapagliflozin can help improve heart function in people who are on regular dialysis and also have heart failure. **You may be eligible if...** - You are between 20 and 70 years old - You have been on dialysis for more than 3 months - You have been diagnosed with chronic heart failure (with weak pumping function or high heart failure markers in your blood) **You may NOT be eligible if...** - You have certain serious heart conditions (such as very low blood pressure, severe valve disease, or recent heart attack) - You have had a recent stroke or are pregnant - You have other conditions that the study team determines make participation unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDapagliflozin

oral Dapagliflozin tablets 10mg/day for 6 months


Locations(1)

The People's Hospital of Gaozhou

Maoming, Guangdong, China

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NCT06365541