Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.
Mechanism Study Under the Role of Tissue Kallikrein-related Peptidase 8 (KLK8)-Induced Senescence of Pulmonary Vascular Endothelial Cells in Ventilator-induced Lung Injury in Elderly People.
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
1,000 participants
Jun 1, 2023
OBSERVATIONAL
Conditions
Summary
1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age. 2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation.
Eligibility
Inclusion Criteria4
- Lung tissues from patients with different ages:
- Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3;
- Peripheral blood from patients with different ages and duration of mechanical ventilation:
- Patients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3;
Exclusion Criteria4
- Lung tissues from patients with different ages:
- Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
- Peripheral blood from patients with different ages and duration of mechanical ventilation:
- Patients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension/diabetes/coronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
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Interventions
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
Locations(1)
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NCT06367946