RecruitingNot ApplicableNCT06369532

Combination of Neurostimulation and Psychotherapy to Stop Worrying

Stop Worrying, Learn to Let go Through a Combination of Neurostimulation and Psychotherapy


Sponsor

University Hospital, Ghent

Enrollment

85 participants

Start Date

Mar 6, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to investigate whether the combination of transcranial Direct Current Stimulation (tDCS) and cognitive-behavioral therapy (CBT) is more effective for treating repetitive negative thinking (RNT) in patients with the symptom of high rumination. High ruminators will be included (Group1, active tDCS-CBT group; Group2, sham tDCS-CBT group). All patients will receive active or sham tDCS.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria2

  • Generalized anxiety disorder (GAD)
  • Depressive disorder

Exclusion Criteria7

  • other psychiatric pathology than GAD or depression screened by senior psychiatrist by means of the Mini-International Neuropsychiatric Interview (MINI) and psychiatric anamnesis
  • Abuse of alcohol, drugs or medication other than prescribed by general practitioner or psychiatrist
  • no consent to participate in measurement (questionnaire, fNIRS or EEG)
  • Insufficient knowledge of the current language (Dutch)
  • Acute or chronic suicidality
  • Acute psychosis or manic depressive disorder
  • Inability to commit to 8 sessions of Cognitive-Behavioral Therapy (CBT) or receive 4 weeks of transcranial Direct Current Stimulation (tDCS).

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Interventions

DEVICEActive tDCS

During the whole therapy period, active tDCS group will receive active tDCS after CBT. They also receive active home-based tDCS.

DEVICESham tDCS

The sham tDCS group will receive sham tDCS after CBT. They also receive sham home-based tDCS.


Locations(1)

University Hospital Ghent

Ghent, East-Flanders, Belgium

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NCT06369532


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