ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study
Abundance of a Natural Odour in Human Cerebrospinal Fluid After Olfactory Exposure - the OLFO-Brain Study
University Hospital, Basel, Switzerland
32 participants
Apr 14, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.
Eligibility
Inclusion Criteria9
- Age 18-60 years
- Written informed consent
- Scheduled for routine liquor puncture
- BMI ≥ 30 kg/m2
- No proven diagnose of diabetes
- Age 18-60 years
- Written informed consent
- Scheduled for routine liquor puncture
- BMI 18-25 kg/m2
Exclusion Criteria6
- Known allergy to the natural odour
- Acute upper respiratory tract infection, acute or chronic sinusitis
- Present or past surgical intervention of the nasal cavity, the paranasal sinus, the pituitary or the frontal brain
- Pregnancy/lactation
- Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease, severe renal impairment with an estimated glomerular filtration rate <30 ml/min/m2)
- Inability to understand the study procedure and to sign the study consent
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Interventions
Inhalation of 50 uL of a natural odour via nasal septum mini-inhaler.
Inhalation of 50 uL of Placebo via nasal septum mini-inhaler.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06370845