RecruitingNCT06372613

Association Between LRG and Histologic Remission in Ulcerative Colitis

What is the Level of Serum Leucine-rich α 2-glycoprotein (LRG) Which Predicts Histologic Remission in Patients With Ulcerative Colitis?


Sponsor

Showa Inan General Hospital

Enrollment

100 participants

Start Date

Feb 25, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

We attempt to clarify the serum leucine-rich α 2-glycoprotein (LRG) level which can predict histologic remission in ulcerative colitis patients in this study. Colonoscopy with histology will be performed when histologic remission is predicted, irrespective of symptoms or serum LRG values. Serum LRG levels are analyzed by an enzyme-linked immunosorbent assay.


Eligibility

Min Age: 20 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a blood protein called LRG (leucine-rich alpha-2-glycoprotein) can serve as a reliable marker to detect when a person with ulcerative colitis has achieved complete healing of the gut lining — known as histologic remission. Currently, confirming remission requires a colonoscopy with biopsy. If LRG can predict this, it may allow doctors to monitor patients less invasively with a simple blood test. **You may be eligible if...** - You are an adult with active ulcerative colitis (an inflammatory bowel disease causing inflammation and ulcers in the large intestine) - You are currently receiving treatment for ulcerative colitis and your doctor is monitoring your response **You may NOT be eligible if...** - There are no specific exclusion criteria listed for this study — speak with the research team to confirm your eligibility Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Showa Inan General Hospital

Komagane, Japan

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NCT06372613