Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants
Target Oxygen Saturation Ranges in Infants With Bronchopulmonary Dysplasia Associated Pulmonary Hypertension
University of Alabama at Birmingham
39 participants
Apr 1, 2026
INTERVENTIONAL
Conditions
Summary
Around 50% of infants born extremely preterm develop a chronic lung disease known as bronchopulmonary dysplasia of which some infants will also develop pulmonary hypertension of which 50% of children will die before the age of 2. Physicians are currently limited in their ability to select the most appropriate oxygen targets that will improve outcomes in infants with this condition. This clinical trial will determine whether using different amounts of oxygen improve outcomes in infants with this disease.
Eligibility
Inclusion Criteria4
- Between 22w 0/7d and 31w 6/7d gestation at birth
- Diagnosed with echocardiographic pulmonary hypertension (1) \>20% flow of blood across the PDA from the pulmonary to arterial circulation, (2) end-systolic flattening of the interventricular septum (eccentricity index \>1.3), or (3) right ventricular pressure estimates ≥ 35 mm Hg
- Receiving supplemental oxygen
- Have mature retinas
Exclusion Criteria1
- Major congenital anomalies
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Interventions
The intervention will be a cross over exposure to the higher oxygen saturation target.
The intervention will be a cross over exposure to the lower oxygen saturation target.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06373289