Pulmonary Hypertension Clinical Trials

103 recruiting

Pulmonary Hypertension Trials at a Glance

136 actively recruiting trials for pulmonary hypertension are listed on ClinicalTrialsFinder across 6 cities in 46 countries. The largest study group is Not Applicable with 22 trials, with the heaviest enrollment activity in Durham, New York, and Milwaukee. Lead sponsors running pulmonary hypertension studies include Chinese Pulmonary Vascular Disease Research Group, China-Japan Friendship Hospital, and Mayo Clinic.

Browse pulmonary hypertension trials by phase

Treatments under study

About Pulmonary Hypertension Clinical Trials

Looking for clinical trials for Pulmonary Hypertension? There are currently 103 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pulmonary Hypertension trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pulmonary Hypertension clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 136 trials

Recruiting
Phase 2

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

Pulmonary Hypertension
Pfizer36 enrolled44 locationsNCT07073820
Recruiting

DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Interstitial Lung DiseasePulmonary HypertensionPulmonary Hypertension Due to Lung Diseases and Hypoxia
United Therapeutics900 enrolled62 locationsNCT06388421
Recruiting

NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot

SepsisStrokePulmonary Hypertension+4 more
St. Olavs Hospital180 enrolled1 locationNCT06646250
Recruiting
Phase 2

A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

Cardiovascular DiseasesFibrosisLung Diseases+3 more
Pulmovant, Inc.20 enrolled1 locationNCT07333183
Recruiting
Not Applicable

iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH

Pulmonary Hypertension
Children's Hospital of Philadelphia25 enrolled1 locationNCT05442671
Recruiting
Phase 1Phase 2

Feasibility of Semaglutide in Advanced Lung Disease

ObesityChronic Obstructive Pulmonary DiseaseInterstitial Lung Disease+2 more
University of Pennsylvania8 enrolled1 locationNCT05746039
Recruiting

Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.

Heart FailurePulmonary Hypertension Due to Left Heart DiseasePulmonary Hypertension (PH)
Hospital General Universitario Gregorio Marañon150 enrolled1 locationNCT07537517
Recruiting
Phase 3

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Interstitial Lung DiseasePulmonary Hypertension
Insmed Incorporated344 enrolled68 locationsNCT07179380
Recruiting

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

Pulmonary DiseasePulmonary Hypertension
National Institutes of Health Clinical Center (CC)270 enrolled1 locationNCT01730092
Recruiting
Not Applicable

Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease

ExerciseExercise TrainingCOPD+2 more
University of Colorado, Denver60 enrolled1 locationNCT05896579
Recruiting

Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization

Pulmonary HypertensionValve Disease, HeartCongestive Heart Failure(CHF)
HemoCept Inc.50 enrolled1 locationNCT07224906
Recruiting

Arterial Wave Energy Flux and Multidimensional Recovery in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Balloon Pulmonary Angioplasty

CTEPHPulmonary Hypertension (PH)
Istanbul Mehmet Akif Ersoy Educational and Training Hospital70 enrolled1 locationNCT07522203
Recruiting

Real World Observational Study of Sotatercept for Pulmonary Hypertension

Pulmonary Hypertension
Mayo Clinic120 enrolled1 locationNCT06751082
Recruiting
Phase 4

Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of Macitentan and Dapagliflozin in Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction (HFmrEF and HFpEF) and Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH)

Group 2 Pulmonary HypertensionHFpEFHFmrEF+2 more
Gachon University Gil Medical Center64 enrolled15 locationsNCT07147114
Recruiting

Collagen Fingerprinting for Stratification of Pulmonary Hypertension (PH) Patients

Pulmonary Hypertension Due to Lung Diseases
Medical University of Graz80 enrolled1 locationNCT07498244
Recruiting
Phase 1

Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension

Lung TransplantPulmonary Hypertension
Mayo Clinic4 enrolled1 locationNCT06770023
Recruiting
Phase 2

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

Pulmonary HypertensionHeart Failure With Preserved Ejection Fraction
Tectonic Therapeutic180 enrolled86 locationsNCT06616974
Recruiting

Insights Into Pediatric Pulmonary Hypertension: A Real-World Registry of Epidemiology and Outcomes

Pulmonary Hypertension
Guangdong Provincial People's Hospital450 enrolled1 locationNCT07495774
Recruiting
Not Applicable

Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants

Pulmonary HypertensionBronchopulmonary Dysplasia
University of Alabama at Birmingham39 enrolled2 locationsNCT06373289
Recruiting
Not Applicable

Development of Novel Physiological CMR Methods in Health and Disease

Heart FailurePulmonary HypertensionMyocardial Infarction+1 more
Sheffield Teaching Hospitals NHS Foundation Trust135 enrolled1 locationNCT03854071