Pulmonary Hypertension Clinical Trials

149 recruitingLast updated: June 17, 2026

There are 149 actively recruiting pulmonary hypertension clinical trials across 46 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4. Top locations include Philadelphia, Pennsylvania, United States, Durham, North Carolina, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Pulmonary Hypertension Trials at a Glance

149 actively recruiting trials for pulmonary hypertension are listed on ClinicalTrialsFinder across 6 cities in 46 countries. The largest study group is Not Applicable with 30 trials, with the heaviest enrollment activity in Philadelphia, Durham, and New York. Lead sponsors running pulmonary hypertension studies include China-Japan Friendship Hospital, Chinese Pulmonary Vascular Disease Research Group, and Mayo Clinic.

Browse pulmonary hypertension trials by phase

Treatments under study

About Pulmonary Hypertension Clinical Trials

Looking for clinical trials for Pulmonary Hypertension? There are currently 111 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pulmonary Hypertension trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pulmonary Hypertension clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 149 trials

Recruiting

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

Pulmonary DiseasePulmonary Hypertension
National Institutes of Health Clinical Center (CC)270 enrolled1 locationNCT01730092
Recruiting
Not Applicable

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Heart FailureCardiovascular DiseasesPulmonary Hypertension+1 more
Abbott Medical Devices850 enrolled68 locationsNCT06526195
Recruiting

DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Interstitial Lung DiseasePulmonary HypertensionPulmonary Hypertension Due to Lung Diseases and Hypoxia
United Therapeutics900 enrolled67 locationsNCT06388421
Recruiting
Phase 3

Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis

Acute Coronary SyndromeTuberculosisPulmonary Hypertension (Diagnosis)
National University Hospital, Singapore150 enrolled6 locationsNCT05473520
Recruiting
Phase 3

A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD

Pulmonary Hypertension Due to Lung Disease (Disorder)
Liquidia Technologies, Inc.344 enrolled6 locationsNCT07285655
Recruiting
Phase 2

A Study of ROC-101 in Patients With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (ILD-PH) (ROCSTAR STUDY)

Pulmonary Arterial Hypertension PAHPulmonary Hypertension, Interstitial Lung Disease
AllRock Bio, Inc.40 enrolled19 locationsNCT07175038
Recruiting
Phase 3

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Interstitial Lung DiseasePulmonary Hypertension
Insmed Incorporated344 enrolled109 locationsNCT07179380
Recruiting
Phase 2

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

Pulmonary Hypertension
Pfizer36 enrolled48 locationsNCT07073820
Recruiting
Not Applicable

Efficacy and Safety of Qishen Yiqi Dropping Pills in Patients With Severe Pulmonary Hypertension

Idiopathic Pulmonary Hypertension
Guangdong Provincial People's Hospital120 enrolled1 locationNCT07604805
Recruiting
Phase 2

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

Chronic Obstructive Pulmonary DiseaseDyspneaPulmonary Hypertension
VA Office of Research and Development126 enrolled5 locationsNCT05937854
Recruiting
Not Applicable

Close Loop Smart Weaning for INO With PPHN

Persistent Pulmonary Hypertension of the NewbornInhaled Nitric Oxide
Children's Hospital of Fudan University30 enrolled1 locationNCT06832163
Recruiting
Not Applicable

Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass

Pulmonary Hypertension
University of Pennsylvania150 enrolled1 locationNCT07132788
Recruiting
Not Applicable

Ventilator Pressure and Optimization of Compliance and Hemodynamics

Pulmonary Hypertension Due to Lung Diseases and HypoxiaBronchopulmonary DysplasiaExtreme Prematurity+2 more
University of Alabama at Birmingham24 enrolled1 locationNCT06512935
Recruiting
Not Applicable

Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease

ExerciseExercise TrainingCOPD+2 more
University of Colorado, Denver60 enrolled1 locationNCT07576894
Recruiting
Not Applicable

Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease

ExerciseExercise TrainingCOPD+2 more
University of Colorado, Denver60 enrolled1 locationNCT05896579
Recruiting
Phase 1

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

AsthmaCOPDCystic Fibrosis+4 more
Mario Castro, MD, MPH260 enrolled1 locationNCT04624490
Recruiting
Not Applicable

Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

Pulmonary HypertensionInterstitial Lung Disease (ILD)
Tempus AI900 enrolled25 locationsNCT06911632
Recruiting

Prevalence, Pathogenesis, and Prognosis of Pulmonary Hypertension in Dialysis Patients

Pulmonary Hypertension
Fondazione IRCCS Policlinico San Matteo di Pavia70 enrolled1 locationNCT07563608
Recruiting
Not Applicable

Safety and PK-PD Study of Oral L-CIT in Preterm Infants With BPD±PH and NEC

Pulmonary HypertensionBPD - Bronchopulmonary DysplasiaNEC
The Hospital for Sick Children36 enrolled1 locationNCT05636397
Recruiting
Not Applicable

Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension

Pulmonary Hypertension
Vanderbilt University Medical Center10 enrolled1 locationNCT07563322