Investigating the Plasticity of Human Predictive Coding Through Neuromodulation
Investigating the Plasticity of Human Predictive Coding Through Neuromodulation: an Interventional, Monocentric, Randomized, Single-blinded Study on Healthy Adult Volunteers
Università Vita-Salute San Raffaele
210 participants
Jun 13, 2024
INTERVENTIONAL
Conditions
Summary
The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.
Eligibility
Inclusion Criteria3
- Participant is willing and able to give informed consent for participation in the study.
- Aged 18-35 years.
- Normal or corrected to normal vision, as per anamnestic investigation.
Exclusion Criteria4
- Participants with a diagnosis of epilepsy (as per anamnestic investigation).
- Participants with major neurological disorders (as per anamnestic investigation).
- Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).
- Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).
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Interventions
tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)
tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)
tACS applied to frontal areas at 4-7 Hz
tRNS applied to occipital brain regions
tRNS applied to frontal brain regions
tACS is activated only for 30 seconds and then turned off, thus resulting ineffective
tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06374433