RecruitingPhase 3NCT06376916

Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR

Atrial Tachycardia Reduction With Intravenous Use of Magnesium (ATRIUM) Study: Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR


Sponsor

Wake Forest University Health Sciences

Enrollment

153 participants

Start Date

Oct 7, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two doses of magnesium (2g vs 4g) versus a placebo (inactive treatment) to see which is most effective at slowing the heart rate in patients with atrial fibrillation with a rapid ventricular rate (a fast, irregular heartbeat) in the emergency setting. **You may be eligible if...** - You are 18 or older - You have been diagnosed with atrial fibrillation with a rapid heart rate (120 beats per minute or more) - You are currently being treated with diltiazem for rate control - You are English-speaking and able to give consent **You may NOT be eligible if...** - You have dangerously low blood pressure - You are in kidney failure requiring dialysis - You are having an acute heart failure episode - You are having a heart attack - You are pregnant - You are hemodynamically unstable or have impaired consciousness - Your rapid heart rate is thought to be compensating for another medical problem Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMagnesium Sulfate 2 G

Magnesium Sulfate 2g for the treatment of atrial fibrillation or atrial flutter with rapid ventricular response (AFF RVR)

DRUGMagnesium Sulfate 4 G

Magnesium Sulfate 4g for the treatment of atrial fibrillation or atrial flutter with rapid ventricular response (AFF RVR)

DRUGSaline

The control group will receive a bolus of normal saline of the same volume and infused over 15 minutes.


Locations(1)

Advocate Christ Medical Center Emergency Department (ACMC ED)

Oak Lawn, Illinois, United States

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NCT06376916


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