RecruitingPhase 3NCT06376994

Multi-Center Clean Air Randomized Controlled Trial in COPD


Sponsor

JHSPH Center for Clinical Trials

Enrollment

770 participants

Start Date

May 24, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing COPD exacerbation risk and improving quality of life, functional status, rescue medication use.


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This randomized controlled trial is testing whether using high-quality air purifiers at home reduces breathing problems and flare-ups in people with COPD (a chronic lung disease often caused by smoking). **You may be eligible if...** - You are 40 years or older - You have a doctor's diagnosis of COPD confirmed by breathing tests - You have a smoking history of at least 10 pack-years (e.g., 1 pack per day for 10 years) - You are a former smoker who quit at least 6 months ago - You have significant COPD symptoms or had a moderate-to-severe flare-up in the past year **You may NOT be eligible if...** - You are still smoking - You do not have confirmed COPD on lung function testing - You have not had significant COPD symptoms or exacerbations - You have other conditions that would prevent safe participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEAir cleaner

The intervention is two active air cleaners with high efficiency particulate air (HEPA) filters which remove PM, as well as activated carbon filters to remove NO2 (and other trace gases). These will be run for a year in a participant's house.

DEVICESham air cleaner

The sham intervention is two sham air cleaners that have the internal HEPA and carbon filters removed, but which will run normally, including similar noise, airflow, and overall appearance compared to active air cleaners, thus blinding participants to filter status. These will be run for a year in a participant's house.


Locations(11)

University of Alabama, Lung Health Center

Birmingham, Alabama, United States

University of California, Los Angeles

Los Angeles, California, United States

University of Iowa

Iowa City, Iowa, United States

University of Maryland

Baltimore, Maryland, United States

Johns Hopkins

Baltimore, Maryland, United States

Tidal Health

Salisbury, Maryland, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

University of Michigan

Ann Arbor, Michigan, United States

Dartmouth Hitchcock

Lebanon, New Hampshire, United States

Cleveland Clinic

Cleveland, Ohio, United States

Reading Hospital

West Reading, Pennsylvania, United States

View Full Details on ClinicalTrials.gov

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NCT06376994


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