Non-steroidal Anti-inflammatory in Cardiac Surgery
Effect of Non-steroidal Anti-inflammatory Drugs in Pain Management After Cardiac Surgery
Centre Hospitalier Universitaire, Amiens
238 participants
Mar 27, 2024
INTERVENTIONAL
Conditions
Summary
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.
Eligibility
Plain Language Summary
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Interventions
o Pain management in both arms Intraoperative time: intravenous ketamine 0.5 mg kg-1, intravenous dexamethasone 8 mg Postoperative time: paracetamol 1 g every 6 hours a day, nefopam 20 every 8 hours a day, patient control analgesia with morphine or oxycontin
Ketoprofen 100 mg twice a day, during 48 after surgery, intravenous administration
Placebo twice a day, during 48 h after surgery, intravenous administration
Locations(1)
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NCT06381063