RecruitingNot ApplicableNCT06381635

Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis

Synergistic Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis in Head and Neck Cancer Patients: Randomized Controlled Clinical Trial


Sponsor

Ain Shams University

Enrollment

40 participants

Start Date

Apr 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this \[ type of study: Clinical trial\] is to test effectiveness of Aloe Vera Gel and Manuka Honey in management of Radiation Induced Mucositis in head and neck cancer patients. The main question \[s\] \] is to \[ learn about, test, compare etc.\] it aims to answer are: 1. Is Aloe Vera Gel and Manuka Honey effective in management of Radiation Induced Mucositis? 2. Does Aloe Vera Gel and Manuka Honey affect the level of TGFβ1 and EGF in saliva of patients with radiation induced mucositis? participants will be asked to apply Aloe Vera Gel and Manuka Honey or saline three times daily during radiotherapy and 6 months after radiotherapy.


Eligibility

Min Age: 20 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether applying aloe vera gel or manuka honey to the inside of the mouth can reduce painful mouth sores (oral mucositis) that commonly develop in patients receiving radiation therapy to the head and neck area. **You may be eligible if...** - You have a confirmed head and neck cancer being treated with radiation (not palliative) - You are receiving 50–70 Gy of radiation (a standard dose range) - You are also receiving chemotherapy alongside radiation - You already have mouth sores from radiation - You are between 20 and 70 years old - You are willing and able to complete the study **You may NOT be eligible if...** - You have diabetes - You received radiation therapy in the past 6 months - You are considered a vulnerable patient (e.g., unable to give proper consent) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTManuka honey mixed with aloe vera gel

a mix gel of manuka honey and with aloe vera honey (1:1) mixed in water bath to get a homogenous mix is then packed in unmarked bottles.


Locations(2)

ain shams University

Cairo, Egypt

Fatma E.Sayed

Cairo, Egypt

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NCT06381635