Hyperpolarized (HP) 13C Pyruvate Magnetic Resonance Imaging (MRI) for Response Monitoring to Neoadjuvant Abiraterone
Hyperpolarized (HP) 13C Pyruvate Magnetic Resonance Imaging (MRI) as a Response Monitoring Tool in Patients With High-Risk Prostate Cancer Receiving Neoadjuvant Therapy
Ivan de Kouchkovsky, MD
32 participants
Dec 9, 2024
INTERVENTIONAL
Conditions
Summary
This study will evaluate the use of hyperpolarized 13C MRI (HP 13C MRI) and the HP-derived 13C pyruvate-to-lactate conversion rate constant (kPL) as an early response biomarker in men with treatment-naïve, high-risk, localized or locally advanced prostate cancer receiving neoadjuvant therapy.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Given orally
Given orally
Given IV
Imaging procedure
Planned, standard of care surgical procedure occurring outside of this study.
Imaging procedure
Locations(1)
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NCT06384222