RecruitingPhase 1NCT06384482

SNC115 Injections in Patients With Recurrent/Refractory Small Cell Lung Cancer and Lung Large Cell Neuroendocrine Carcinoma

To Evaluate the Safety and Pharmacokinetic of SNC115 Injections in Patients With Recurrent/Refractory Small Cell Lung Cancer and Lung Large Cell Neuroendocrine Crcinoma: an Open-label, Single-arm, Dose Escalation Exploratory Study


Sponsor

Shanghai Simnova Biotechnology Co.,Ltd.

Enrollment

35 participants

Start Date

Apr 30, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a FIH dose escalation clinical study, with single arm, open label and design, in order to observe the preliminary safety and Pharmacokinetic of SNC115 Injection in participants with Recurrent/refractory small cell lung cancer and Lung large cell neuroendocrine carcinoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new CAR-T cell therapy called SNC115 — where your own immune cells are engineered to attack cancer — for people with small cell lung cancer or a related type of lung cancer (large cell neuroendocrine carcinoma) that has come back or stopped responding to treatment. **You may be eligible if...** - You are 18 or older - You have been diagnosed with small cell lung cancer or pulmonary large cell neuroendocrine carcinoma - Your cancer has relapsed or did not respond to at least one standard treatment - You are in reasonably good health (performance status 0–1) - You have at least one measurable tumor **You may NOT be eligible if...** - You have had previous CAR-T or gene-modified cell therapy - You have untreated or symptomatic brain metastases - You have serious autoimmune disease, heart problems, or uncontrolled fluid around your lungs or heart - You are allergic to key drugs used in the study process Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSNC115 injection

SNC115 Injection is DLL3 CART.


Locations(1)

Shanghai Chest Hospital

Shanghai, Shanghai Municipality, China

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NCT06384482