RecruitingNot ApplicableNCT06386471

Personalized GI Motility Responses to Diet

Personalized Gastrointestinal Motility Responses to Dietary Fiber and Gut Microbial Metabolites

Sponsor

University of Illinois at Urbana-Champaign

Enrollment

50 participants

Start Date

Mar 7, 2024

Study Type

INTERVENTIONAL

Conditions

Nutritional and Metabolic Diseases

Summary

The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3) circulating postprandial appearance of metabolites important to cardiometabolic health including glucose, triglycerides, and cholesterol. Participants will be asked to consume a Smartpill monitoring device that records metrics of gastrointestinal motility in response to whole or refined grains, monitor cardiometabolic metabolties over an 8 hour postprandial window, and provide a fecal sample for microbiome-related analyses.

Eligibility

Min Age: 21 YearsMax Age: 63 Years

Inclusion Criteria1

Healthy men and women

Exclusion Criteria26

Physician-Diagnosed:
Diabetes Mellitus
Nutrient-malabsorption disorders
Intestinal Bowel Syndrome (IBS)
Intestinal Bowel Disease (IBD)
Bleeding-related disorders
Grain allergy
Psychological Disorders
Stenosis
Dysphasia
History of:
Bariatric Surgery
Gallbladder removal
Eating disorders
Antibiotic administration (within the past three months)
Hormone therapy
Currently:
Using statins
Pregnant, lactating, or postmenopausal
Taking oral hypoglycemic agents or insulin
Ingesting prescription fiber
Using cholesterol and bile acid absorption inhibitors
Ingesting nutrition supplements, not including a daily multivitamin (i.e. herbs, tinctures, and extracts) •Using recreational drugs or alcohol (within the past week)
Taking anti-histamines
Taking proton pump inhibitors
Taking antacids