RecruitingPhase 1Phase 2NCT06391190

Concurrent Chemoradiotherapy Followed by PD-1 Inhibitor in Advanced Cervical Cancer

A Prospective Single Arm Trial of Concurrent Chemoradiotherapy (With Albumin-Bound Paclitaxel/Cisplatin) Followed by PD-1 Inhibitor in Locally Advanced Cervical Cancer


Sponsor

RenJi Hospital

Enrollment

20 participants

Start Date

Jan 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

To explore the safety and efficacy of Albumin-Bound Paclitaxel/Platinum based concurrent chemoradiotherapy Followed by PD-1 inhibitor (Sintilimab) in locally advanced cervical cancer


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding a PD-1 inhibitor (an immunotherapy drug that helps the immune system attack cancer) after standard chemoradiation treatment improves outcomes for women with locally advanced cervical cancer. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with locally advanced cervical cancer (not yet spread to distant organs) that has not been treated yet - You are in good enough health to receive radiation and chemotherapy together - Your blood, liver, and kidney function are within acceptable ranges **You may NOT be eligible if...** - Your cancer has already spread to distant parts of the body - You have an active autoimmune disease - You have had an organ transplant or have HIV - You are allergic to the immunotherapy drug being used - You have had another cancer within the past 5 years (except certain non-serious skin cancers) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAlbumin-Bound Paclitaxel, cisplatin, Sintilimab

with Albumin-Bound Paclitaxel 50-75mg/m2, cisplatin 25-40 mg/m2 weekly for up to 5 cycles during radical radiation; followed by Sintilimab 200mg Q3W for 8 cycles


Locations(1)

RenJi hospital

Shanghai, China

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NCT06391190


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