PSMA-Directed Para-Aortic Radiation Therapy for Oligorecurrent Prostate Cancer

This study is testing whether targeted radiation therapy to lymph nodes near the aorta (a region called the para-aortic area) can control prostate cancer that has come back in that region after prior pelvic radiation treatment. The radiation targets are identified using a PSMA PET scan — a highly sensitive imaging tool. **You may be eligible if...** - You are a man aged 18 or older - You have prostate cancer that has returned (recurred) and is limited to the lymph nodes in the pelvis and just above the pelvis (sub-diaphragmatic region) - You have 5 or fewer spots on a PSMA PET/CT scan - You previously had radiation to the prostate or prostate bed - Your cancer is still hormone-sensitive **You may NOT be eligible if...** - Your cancer has spread beyond the sub-diaphragmatic lymph nodes (e.g., to organs or bones) - You have more than 5 spots on your PSMA scan - You have a tumor larger than 5 cm Talk to your doctor to see if this trial is right for you.