RecruitingPhase 1NCT06393738

A Study of ARV-393 in Relapsed/Refractory Non-Hodgkin Lymphoma.

A Phase 1 First in Human Study of ARV-393 in Adult Participants With Advanced Non-Hodgkin's Lymphoma


Sponsor

Arvinas Inc.

Enrollment

255 participants

Start Date

Sep 5, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial is studying the safety and potential anti-tumor activity of an investigational drug called ARV-393 in patients diagnosed with advanced Relapsed/Refractory non-Hodgkin's lymphoma (R/R NHL) to determine if ARV-393 may be a possible treatment option. ARV-393 is thought to work by breaking down a protein present in many types of non-Hodgkins lymphomas, which may prevent, slow or stop tumor growth. This is the first time ARV-393 will be used by people. The investigational drug will be given as an oral tablet.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called ARV-393 in people with relapsed or treatment-resistant non-Hodgkin lymphoma (NHL) — a group of blood cancers that start in white blood cells called lymphocytes — who have run out of standard treatment options. **You may be eligible if...** - You have non-Hodgkin lymphoma that has returned or is no longer responding to treatment - You have received at least 2 prior treatments (including rituximab) - You have at least one measurable tumor on imaging - You are in good health (ECOG performance status 0 or 1; score 2 allowed in some groups with brain involvement) - Your bone marrow, kidney, and liver function are adequate **You may NOT be eligible if...** - You have a history of elevated eosinophils (a type of white blood cell) causing organ problems - You have had a prior allogeneic (donor) stem cell transplant - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGARV-393

Oral daily dose of ARV-393 at a specified dose level

DRUGGlofitamab

Glofitamab infusion per labelled prescribing information


Locations(17)

Clinical Trial Site

New Haven, Connecticut, United States

Clinical Trial Site

Detroit, Michigan, United States

Clinical Trial Site

New Brunswick, New Jersey, United States

Clinical Trial Site

New York, New York, United States

Clinical Trial Site

New York, New York, United States

Clinical Trial Site

Cleveland, Ohio, United States

Clinical Trial Site

Nashville, Tennessee, United States

Clinical Trial Site

Houston, Texas, United States

Clinical Trial Site

Toronto, Ontario, Canada

Clinical Trial Site

Montreal, Quebec, Canada

Clinical Trial Site

Copenhagen, Denmark

Clinical Trial Site

Odense C, Denmark

Clinical Trial Site

El Palmar, Murcia, Spain

Clinical Trial Site

Pamplona, Navarre, Spain

Clinical Trial Site

Barcelona, Spain

Clinical Trial Site

Madrid, Spain

Clinical Trial Site

Salamanca, Spain

View Full Details on ClinicalTrials.gov

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NCT06393738