RecruitingNot ApplicableNCT06398548

Impact of Exercise Intensity on Fitness, Extracellular Vesicles, Inflammation, and Metabolism

The Impact of 6 Weeks of Moderate- and Heavy-intensity Continous Training on Peak Oxygen Uptake, Plasma Extracellular Vesicles and Inflammatory Cytokines

Sponsor

University of British Columbia

Enrollment

50 participants

Start Date

May 1, 2023

Study Type

INTERVENTIONAL

Conditions

Exercise Training

Summary

Introduction This study investigates the effects of different intensities of indoor cycling on various health measures. Participants will perform a maximal cycling test to determine their maximal fitness - a strong predictor of overall health - before and after a 6-week training intervention. Blood samples will also be obtained to look at various physiological markers related to extracellular vesicles, inflammation, and metabolism. Who can participate? Healthy young adults who between 18 and 40, are free of immune disease, with a normal body mass index can join this study. They will be divided into three groups: * One group will ride a bike at a moderate pace. * Another group will ride a bike at a slightly harder pace. * The third group won't change their usual daily activities and will continue living as they normally do. What does the study involve? Each exercise session aims to burn a specific amount of calories: 350 for males and 300 for females. Participants cycle 3 times a week for 6 weeks. At the end, we'll repeat the bike test and take another blood sample to see if there have been any changes due to the exercise. Why is this research being done? The researchers want to see how different intensities of exercise impact health and fitness. This may help people make better choices about how much and what type of exercise they should do. What happens after the study? Researchers will analyze the data from the study and see if any differences exist between the protocols. If the participant is interested, we will also provide their blood test results, and the results from their max test.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria4

Are between the ages of 18 and 40 years old.
Have a body mass index (BMI) between 18.5 and 30 kg/m\^2.
Perform between 60 and 200 minutes of aerobic physical activity per week.
Do not have a history of cardiovascular disease or diabetes.

Exclusion Criteria7

Require immunomodulatory medication to treat an auto-immune disease, or rely heavily on over the counter anti-inflammatory medications (e.g., Advil).
Have a metabolic condition such as diabetes.
Have hypertension (blood pressure > 160/90 mmHg).
Are uncomfortable with blood sampling.
Are an elite endurance athlete, or training specifically for an endurance event (>3 structured aerobic training sessions, or >150 min of specific aerobic-based/endurance training per week).
Adhere to an extreme diet (e.g., ketogenic diet, time restricted feeding).
Smoke cigarettes

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Interventions

OTHERControl Group

Participants continue with their lifestyle as usual, with no modification to lifestyle, or exercise habits.

OTHERModerate Intensity Continuous Training

This group cycles at 70% of the resistance associated with their first lactate threshold.

OTHERHeavy Intensity Continuous Training

This group cycles at 10% of the difference between the resistance associated with their lactate threshold, and maximal achieved watts, added to the resistance associated with their lactate threshold.