A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

This study is testing a new drug called APL-5125 in people with advanced solid tumor cancers that no longer respond to standard treatments. The early phase focuses on colorectal, bile duct, and appendix cancers, with later phases including more tumor types. **You may be eligible if...** - You are 18 or older and weigh at least 40 kg - You have an advanced solid tumor cancer (such as colorectal, bile duct, appendix, pancreatic, endometrial, triple-negative breast, ovarian, or prostate cancer) - Standard treatments are no longer available or working for you - You have adequate heart, liver, kidney, and blood function **You may NOT be eligible if...** - You have active brain metastases (cancer spread to the brain) - You have had a heart attack, unstable angina, or significant bleeding in the last 4–6 weeks - You have had major surgery in the last month - You are HIV positive (unless well-controlled), or have active hepatitis B or C - Your blood counts or organ function are below required levels - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.