RecruitingNCT06400095

Ventilatory Parameters in Predicting Outcomes in ARDS Patients

Occlusion Pressure at 100 Msec, TCe ( Expiratory Time Constant ), Stress Energy Density, Mechanical Power, Ventilatory Ratio and C20/Cdyn in Predicting Outcomes in Patients With Moderately Severe ARDS, Who Are on Mechanical Ventilation

Sponsor

CentraCare

Enrollment

50 participants

Start Date

Jun 1, 2023

Study Type

OBSERVATIONAL

Conditions

ARDS Mechanical Power

Summary

This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation

Eligibility

Min Age: 19 YearsMax Age: 80 Years

Inclusion Criteria2

Patients with Acute respiratory failure needing mechanical ventilation
Diagnosis of Severe ARDS with severity: PF ratio \< 150, with PEEP/CPAP \> 5

Exclusion Criteria10

r2 \< 0.95, monitored on the ventilator
Expiratory flow that is not first-order or non-exponential decay
Patients with Nor-epinephrine requirements \> 0.1 mcg/kg/min within 2 hours of intubation
Patients requiring ECMO ( Extracorporeal membrane oxygenation)
Patients with COPD or pulmonary fibrosis with a premorbid FEV1 \< 1.5 L
Severe atherosclerotic vascular disease
Patients with a chest tube, intra-abdominal hypertension or with its risk factors
Patients with structural heart disease including pulmonary hypertension (RVSP \> 45) and heart failure
All comfort care orders in the ICU
Patients who underwent tracheostomy

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