RecruitingNot ApplicableNCT06400563

MRg-NIRS Imaging System Breast Cancer Trial

Evaluation of the Magnetic Resonance-guided (MRg) Near-infrared Spectroscopy (NIRS) Imaging System Platform in Breast Cancer Patients


Sponsor

Keith D. Paulsen

Enrollment

20 participants

Start Date

Sep 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This trial is a study of 20 women with breast cancer to evaluate the addition of MR-guided (MRg) near-infrared spectroscopy (NIRS) with and without contrast, as part of a program to improve clinical management of women receiving breast magnetic resonance imaging (MRI).


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 83 Years

Inclusion Criteria5

  • Females age ≥ 18 years old
  • Participants capable of providing written informed consent
  • Women with a recent diagnosis of breast cancer.
  • Women who are in pre-surgical planning must have an estimated tumor size of 2.0 cm or less on available imaging.
  • Women who are in pre-surgical planning must have had a breast biopsy at least 10 days prior to the MRg-NIRS exam.

Exclusion Criteria9

  • Participants with absolute or relative contraindication to MRI:
  • the presence of an electronic implant, such as a pacemaker
  • the presence of a metal implant, such as an aneurysm clip
  • claustrophobia
  • renal failure (FDA's guidance for gadolinium of a creatinine clearance less than 30 mL/1.73 m2 BSA)
  • Pregnant women
  • Breast implants
  • Prisoners
  • Participants with visually inadequate healing from breast biopsy.

Interventions

DEVICEMRg-NIRS

The trial tests the investigator designed and developed Magnetic Resonance-guided (MRg) Near-infrared Spectroscopy (NIRS) imaging system for breast cancer detection. The wearable NIRS imaging system uses 8 flex circuit strips, each with six photo-detectors (PDs) and six source fibers, that are ready to attach to a breast radially by using an adhesive nipple cover and breast tape.


Locations(1)

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

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NCT06400563


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