RecruitingPhase 3NCT06401356

An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

An Open-Label, Multicenter, Extension Study for Patients Previously Enrolled in Studies With Pelabresib


Sponsor

Novartis Pharmaceuticals

Enrollment

50 participants

Start Date

Aug 13, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the long-term safety and the clinical benefit of pelabresib in patients with hematological and/or solid tumor indications or advanced malignancies. Additionally, participants previously enrolled in studies with pelabresib who received placebo or participants who discontinued pelabresib (for any other reason than participating in this extension study), may be enrolled in this extension study to evaluate the survival and leukemia-free survival (for patients with hematological malignancies) or only the Survival Follow-up (for all the other patients).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Pelabresib for people with advanced malignancies, hematologic malignancy, and other related conditions. The study is currently recruiting participants at 15 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPelabresib

Small molecule inhibitor of bromodomain and extraterminal (BET) protein


Locations(15)

University of California LA

Los Angeles, California, United States

Mayo Clinic Jacksonville

Jacksonville, Florida, United States

Northwestern University

Chicago, Illinois, United States

Uni Of Michigan Health System

Ann Arbor, Michigan, United States

New York Presbyterian Hospital

New York, New York, United States

Mt Sinai Medical Center

New York, New York, United States

Novartis Investigative Site

Antwerp, Belgium

Novartis Investigative Site

Bruges, Belgium

Novartis Investigative Site

Florence, FI, Italy

Novartis Investigative Site

Varese, VA, Italy

Novartis Investigative Site

Novara, Italy

Novartis Investigative Site

Amsterdam, Netherlands

Novartis Investigative Site

Cardiff, United Kingdom

Novartis Investigative Site

Glasgow, United Kingdom

Novartis Investigative Site

London, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06401356


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