RecruitingNCT06402981

A Clinical Study on the Analysis of Risk Factors for the Occurrence of PD-1/PD-L1 Inhibitor-associated Liver Injury in Lung Cancer Patients


Sponsor

Zhejiang University

Enrollment

2,000 participants

Start Date

Jan 1, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to investigate the risk factors of PD-1/PD-L1 inhibitor-associated liver injury, to construct a prediction model for the occurrence of liver injury. The main questions it aims to answer are: * Exploring risk factors for liver injury. * Constructing a Predictive Model for the Occurrence of Liver Injury in PD-1/PD-L1 Inhibitor-Related Liver Injury. * Improving immunotherapy protocols for lung cancer patients.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This observational study is looking at what factors put lung cancer patients at higher risk of developing serious side effects from immunotherapy drugs (PD-1/PD-L1 inhibitors). It collects data from patients already receiving these treatments to identify patterns and risk factors. **You may be eligible if...** - You have been diagnosed with lung cancer - You have received at least one course of a PD-1 or PD-L1 inhibitor (a type of immunotherapy) - You are between 18 and 80 years old **You may NOT be eligible if...** - You had significant liver injury before starting immunotherapy (liver enzyme levels more than 5 times the normal limit) - Your doctor believes your participation in the study would not be appropriate for you personally Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERHigh risk prediction model for liver injury

Risk Prediction Model for Liver Injury After Use of PD-1/PD-L1 Inhibitors


Locations(1)

The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06402981


Related Trials