RecruitingPhase 1NCT06403436

A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors

A Phase 1, First-in-Human, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors


Sponsor

TOLREMO therapeutics AG

Enrollment

50 participants

Start Date

Nov 7, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to test the safety and therapeutic effect of TT125-802 (single agent) in subjects with advanced solid tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is an early-phase (Phase I) study testing the safety, tolerability, and dosing of an experimental cancer drug in people with advanced solid tumors that have stopped responding to standard treatments. **You may be eligible if...** - You are 18 or older with an advanced solid tumor that is resistant to or has stopped responding to standard treatment - Your tumor can be measured on a scan - Your general health score is 0 or 1 (fully active or able to do light work) - Your blood counts, liver, kidney, and clotting function are within acceptable ranges - Your expected survival is more than 3 months - You are not pregnant or breastfeeding and are willing to use contraception if needed **You may NOT be eligible if...** - You have received cancer treatment (chemo, targeted therapy, immunotherapy) within the past 4 weeks - You have significant heart, kidney, or liver disease - You have had major surgery within 4 weeks - You have active brain metastases (cancer that has spread to the brain) - You have a serious bleeding or clotting disorder Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTT125-802

TT125-802 administered orally


Locations(7)

Sarah Cannon Research Institute Oncology Partners

Nashville, Tennessee, United States

NEXT Oncology Virginia

Fairfax, Virginia, United States

NEXT Oncology Barcelona

Barcelona, Spain

Vall d'Hebron Institute of Oncology

Barcelona, Spain

NEXT Oncology Madrid

Madrid, Spain

Ente Ospedaliero Cantonale

Bellinzona, Switzerland

Centre Hospitalier Universitaire Vaudois

Lausanne, Switzerland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06403436


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