Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
University of Maryland, College Park
350 participants
Aug 1, 2024
INTERVENTIONAL
Conditions
Summary
The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of life. By seeking to better understand post-stroke aphasia, this project lays the groundwork for development of new interventions, and aligns with NIDCD's priority areas 1 (understanding normal function), 2 (understanding diseases), and 3 (improving diagnosis, treatment, and prevention).
Eligibility
Inclusion Criteria4
- At least 18 years of age
- Persons with acquired aphasia are defined as those with a language impairment following left hemisphere brain injury (most likely a stroke).
- Neurotypical adults need to be either young (ages 18-30 years) or older (\> 60 years)
- Native (or primary) speakers of English
Exclusion Criteria2
- Prior neurological or psychiatric diagnoses or developmental disabilities before the onset of aphasia
- do not speak English fluently
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Interventions
The intervention involves asking participants to speak and understand words and sentences with different linguistic manipulations such as morphological, semantic, phonological priming, predictability of the subject and object nouns associated with verbs, naming of verbs and nouns, production of sentences with past, future or present tense. Accuracy, response times and brain activity are the outcome measures.
Locations(1)
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NCT06405594