Topical Application of PRF Before Radiation Therapy
Topical Application of PRF in Tooth Extraction Sockets Before Radiation Therapy for Head and Neck Cancer
University of Giessen
34 participants
Dec 1, 2023
INTERVENTIONAL
Conditions
Summary
The primary goal of this study is to observe whether PRP promotes the wound healing before a radiation therapy or not, compared to the natural healing of a tooth extraction socket. Secondary aim is to monitore the effect on the pain perception.
Eligibility
Inclusion Criteria5
- Head and neck cancer with planed radiation therapy
- Bilateral tooth extraction
- Similar tooth size
- Atraumatic tooth extractions without flap surgery
- Patients age above 18y of age
Exclusion Criteria3
- Prior radiation therapy in the head and neck area
- Prior and current therapy with bisphosphonates or equivalent modern biologics
- Patients during pregnancy or breastfeeding
Interventions
Patients blood is standardized centrifuged and split in to a red-phase (erythrocytes) and white-phase (PRF). The gained PRF is processed to a clot-fort and is inserted into the alveolus.
After the tooth extraction, natural healing is aimed by allowing a blood clot formation without any further intervention.
Locations(1)
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NCT06406530