Patient-derived Organoid Drug Sensitivity Guided Treatment for Recurrent Small Cell Lung Cancer

This study uses tiny lab-grown tumor models (organoids) built from a patient's own cancer cells to guide treatment choices for small cell lung cancer that has come back after prior treatment. The goal is to personalize therapy based on what actually works against that patient's tumor. **You may be eligible if...** - You are 18 to 75 years old - You have small cell lung cancer that has relapsed or progressed - You have completed at least one prior systemic treatment - You are in adequate health (ECOG score 0–2) - You have at least one tumor that can be biopsied for organoid testing - Your expected survival is 3 months or more **You may NOT be eligible if...** - Your cancer has not progressed after your last treatment - You are too unwell to receive further treatment - Your tumor cannot be safely sampled for organoid testing Talk to your doctor to see if this trial is right for you.