RecruitingPhase 1Phase 2NCT06406777

Chronic Lung Allograft Dysfunction MRI Study

Validation of MRI, CT and Pulmonary Function Tests for Early Detection of Chronic Lung Allograft Dysfunction

Sponsor

Sean Fain

Enrollment

100 participants

Start Date

Mar 20, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic Lung Allograft Dysfunction Lung MRI (CLAD)

Summary

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 129Xe MRI scans, Contrast Lung Computed Tomography (CT) Scan, and others for people with chronic lung allograft dysfunction lung mri (clad). The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTSpirometry

Spirometry measures lung function, specifically the amount and/or speed of air that can be inhaled and exhaled.

DIAGNOSTIC_TESTContrast Lung Computed Tomography (CT) Scan

CT scan of the lungs using contrast

DIAGNOSTIC_TESTOxygen enhanced magnetic resonance imaging (OE-MRI) Scan

MRI will be taken while subject is lying on their back breathing 100% oxygen.

DRUG129Xe MRI scans

MRI will be taken while subject is lying on their back breathing room oxygen and taking a breath of 129Xe and holding it for a few seconds.

Locations(1)

University of Iowa

Iowa City, Iowa, United States

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NCT06406777