Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)

Exclusion Criteria15

• Has traumatic brain injury, stroke, multiple sclerosis, or other neuromuscular disorders that could affect neuromotor function and walking.
• Has severe spasticity that could prevent stepping and walking function determined by the investigator.
• Has major executive dysfunction, dementia, depression, neurocognitive impairments, or other major medical co-morbidities.
• Has other contra-indications for transcranial magnetic stimulation (TMS) or Transcutaneous Spinal Cord Stimulation (TSCS).
• Has a history of recent seizures or poorly managed autonomic dysreflexia that could be triggered by TMS or TSCS.
• Has a history of prior intracranial surgery or known lesions that would limit TMS assessments and Brain-Computer Interface (BCI) recordings.
• Individuals with metal implants in their head and other implantable devices in the body that could be affected by TMS or TSCS.
• Has peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy, etc.).
• Has urinary tract infection, unhealed fracture, contracture, and pressure sore (Braden Scale).
• Has breakdown in skin area that will come into contact with electrodes.
• Individuals who require therapy or other care that could interfere with participation in the study.
• Individuals on investigational drugs or any other intervention known to have a potential impact on neuromotor function.
• Individuals with substance disorders, including alcoholism and drug abuse.
• Individuals who are pregnant, breastfeeding, or the desire to become pregnant during the study.
• In the opinion of the investigators, the study is not safe or appropriate for the participant.