RecruitingPhase 2NCT06408116
Predicting Esophageal Cancer Borders Using PET-Imaging
Predicting Esophageal Cancer Borders Using PET-Imaging PEGASUS
Sponsor
University Hospital Heidelberg
Enrollment
30 participants
Start Date
Mar 1, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The study examines the diagnostic precision of endosonography, mpMRI and PET/CT in defining tumor boundaries and tumor spread before and after neoadjuvant therapy and definitive surgery.
Eligibility
Min Age: 18 Years
Inclusion Criteria6
- Histologically confirmed adenocarcinoma or squamous cell carcinoma of the esophagus, including AEG I and AEG II tumors in the primary situation
- Planned surgical treatment of esophageal carcinoma
- Possible staging advantage through FAPI PET/CT diagnostics
- Patient information and written consent
- \> KI 60% or ECOG 0/1 (at least: self-sufficiency)
- Age ≥ 18 years
Exclusion Criteria9
- Previous radiation therapy in the tumor region
- Previous tumor disease with \< 5 years of remission
- Surgical therapy is not functionally or technically possible
- Distant metastasis
- Patient is not capable of giving consent
- Concurrent participation in another clinical trial that could affect the results of this trial or the other trial
- Illnesses that do not allow the person concerned to assess the nature and scope as well as possible consequences of the clinical study
- pregnant or breastfeeding women
- Signs that the person taking part is unlikely to comply with the therapy (e.g. unwillingness to cooperate)
Interventions
RADIATIONphoton
radiation with 4-5 cm safte margin
PROCEDUREsurgical therapy
surgery based on PET-CT/MRI staging
DRUGChemotherapy
neoadjuvant chemotherapy
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06408116