Effectiveness of MST Versus ECT for Major Depressive Episode

This trial compares two brain stimulation therapies — magnetic seizure therapy (MST) and electroconvulsive therapy (ECT) — for people with severe major depression. Both involve brief electrical or magnetic stimulation of the brain under anesthesia; this study examines which works better with fewer side effects. **You may be eligible if...** - You are 18 to 65 years old - You have a confirmed diagnosis of major depressive disorder (MDD) - Your depression is severe (Hamilton Rating Scale score of 18 or higher) - You are taking one stable antidepressant medication **You may NOT be eligible if...** - You have a history of certain neurological conditions (e.g., seizure disorder) - You have a pacemaker, metal implants, or other contraindications to brain stimulation - You have bipolar disorder or another primary psychiatric diagnosis - You are under 18 or over 65 Talk to your doctor to see if this trial is right for you.