RecruitingNCT06410300

Cardiopulmonary Monitoring in Lung Cancer Patients Receiving Combined Thoracic Radiotherapy and Immunotherapy

A Multi-Center Pilot Biomarker Study With Cardiopulmonary Monitoring in Lung Cancer Patients Receiving Combined Thoracic Radiotherapy and Immunotherapy


Sponsor

Bo Lu

Enrollment

125 participants

Start Date

Apr 19, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The overall purpose of this study is to evaluate cardiopulmonary toxicity in patients with lung cancer (NSCLC or SCLC) undergoing combined thoracic radiotherapy ± chemotherapy and immunotherapy through timed monitoring and blood sample collection and to identify correlative biomarkers for predicting cardiopulmonary adverse events.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study monitors the heart and lung health of lung cancer patients who are receiving radiation therapy combined with immunotherapy. Researchers want to better understand how this combination treatment affects the heart and lungs over time. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with locally advanced lung cancer (non-small cell or small cell) - You are planned to receive radiation therapy (at a significant dose) followed by immunotherapy - You are in reasonably good physical condition (able to carry out light work) - Your expected lifespan is at least 6 months **You may NOT be eligible if...** - You have previously received radiation to the chest - You are not a candidate for curative radiation therapy or immunotherapy - You have serious existing medical or psychiatric conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONCurative Radiotherapy

Radiation dose of 45 Gy or higher

DRUGImmunotherapy

checkpoint inhibitor per PI discretion


Locations(3)

University of Missouri - Ellis Fischel Cancer Center

Columbia, Missouri, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

University of Rochester Medical Center

Rochester, New York, United States

View Full Details on ClinicalTrials.gov

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NCT06410300


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