The Effects of Different Loading Doses of Dexmedetomidine on The Bispectral Index-Guided Propofol Sedation in Patients Undergoing Advanced Upper Gastrointestinal Endoscopic Procedures: A Randomized Control Study
Theodor Bilharz Research Institute
52 participants
May 1, 2024
INTERVENTIONAL
Conditions
Summary
Propofol is currently the most common drug used but has drawbacks like narrow therapeutic window and potential complications. Dexmedetomidine is an attractive alternative due to its unique properties like minimal respiratory depression. Studies are ongoing to find the optimal use of dexmedetomidine for these procedures. A combination of propofol and dexmedetomidine might be ideal, but the best balance between the two drugs needs further investigation.
Eligibility
Inclusion Criteria4
- Patients aged 18-65
- Both sexes
- ASA I-II
- BMI <35
Exclusion Criteria11
- Patients' refusal to participate
- ASA III-IV
- BMI > 35
- Patients who are considered high aspiration risk, e.g., gastric outlet obstruction
- Allergy to any medications used
- Diabetics
- Any patient receiving cardioactive drugs, e.g., Beta blockers, Calcium channel blockers, Inhaled B2 bronchodilators)
- Patients with Pacemakers or heart rate below 50 beat/min
- Pregnant women
- Habitual Drug abusers
- Patients who had to be intubated during the procedure.
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Interventions
The Effects of Different Loading Doses of Dexmedetomidine on The Bispectral Index-Guided Propofol Sedation in Patients Undergoing Advanced Upper Gastrointestinal Endoscopic Procedures: A Randomized Control Study
the group will receive normal saline infusion over 10 minutes.
Locations(1)
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NCT06414395