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RecruitingNot ApplicableNCT06415474

Evolution of the Lymphocyte Phenotype in Patients with Infection in Intensive Care Unit

Sponsor

University Hospital, Brest

Enrollment

80 participants

Start Date

Oct 3, 2024

Study Type

INTERVENTIONAL

Conditions

Patients Undergoing EsophagectomyPatients with Severe PolytraumaPatients with Severe Neurological LesionPatients with Abdominal Infection

Summary

Patients admitted for polytrauma, severe neurological injury, post-operative monitoring or sepsis/septic shock present with significant inflammation, leading to immunoparalysis, which is responsible for infection, particularly prolonged infection. A study of their lymphocyte phenotype over time could help explore the phenomenon of immunoparalysis.

Eligibility

Min Age: 18 Years

Inclusion Criteria11

  • Postoperative esophagectomy surveillance within the last 24 hours.
  • Patients with intra-abdominal infection
  • Neurological patients with intubation planned for more than 24 hours (subarachnoid hemorrhage with coma, severe head trauma, ischemic or hemorrhagic stroke with coma).
  • Polytrauma with intubation planned for more than 24 hours
  • Patient aged 18 and over
  • Patient with social security coverage
  • Hereditary immune deficiency HIV-AIDS
  • Malignant hemopathies
  • Immunosuppressive treatment other than corticosteroid therapy or chemotherapy
  • Patient under legal protection
  • Pregnant or breast-feeding women
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Interventions

PROCEDURELymphocyte Phenotyping Procedure

For all patients, lymphocyte phenotyping will be performed on biological samples taken on D0, D7 and the day of discharge. In case of infection, phenotyping will also be performed on the day of infection diagnosis and on the day corresponding to half the duration of antibiotic therapy. For phenotyping, only 1.5 mL will be used. In case of infection, an additional 1mL will be collected (0.5mL on the day of inclusion diagnosis and 0.5 mL on the day corresponding to half the duration of antibiotic therapy). Blood is collected during sampling, which takes place several times a day as part of the standard management of these patients. It is important to note that phenotyping is not routinely performed as part of routine care. An additional tube is therefore taken specifically for this analysis, but this is done without the need for an additional puncture.

Locations(1)

CHU de Brest

Brest, France

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NCT06415474