Can Needle Size Improve Cancer Detection Rate of Transperineal MRI Target Prostate Biopsy Without Affecting Side Effects?

This study is comparing two different biopsy needle sizes to see whether a thinner needle can detect prostate cancer just as well — or better — while causing fewer side effects. Biopsies are done through the perineum (the area between the legs) using MRI guidance. **You may be eligible if...** - You have a raised PSA (prostate-specific antigen) blood test or an abnormal prostate exam suggesting cancer - An MRI scan shows at least one suspicious area in your prostate (rated PI-RADS 3 or higher) **You may NOT be eligible if...** - You are already on active surveillance for prostate cancer, or you have been previously diagnosed with prostate cancer - You have previously had radiotherapy to your prostate for cancer Talk to your doctor to see if this trial is right for you.