RecruitingNCT06420427

Dynamic Monitoring of ctDNA and HPV DNA in Plasma for the Early Prediction of Recurrence After Cervical Cancer Surgery

Dynamic Monitoring of Circulating Tumor DNA (ctDNA) and HPV DNA in Plasma for the Early Prediction of Recurrence After Cervical Cancer Surgery/Treatment


Sponsor

The Third Affiliated Hospital of Guangzhou Medical University

Enrollment

150 participants

Start Date

Jan 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Assess the sensitivity, specificity, positive predictive value, and negative predictive value of dynamic monitoring of circulating tumor DNA (ctDNA) combined with circulating HPV DNA (cfHPV DNA) for early prediction of recurrence in cervical cancer post-surgery or post-treatment, and compare its advantages and disadvantages with existing diagnostic methods.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is monitoring blood samples from cervical cancer patients to detect early signs that cancer may be coming back after treatment. It looks for tiny fragments of tumor DNA (ctDNA) and HPV virus DNA circulating in the blood — like a liquid biopsy that could catch recurrence sooner than imaging. **You may be eligible if...** - You are 18 or older - You have newly diagnosed HPV-positive cervical cancer (stages I–IV) - You have not yet had surgery, radiation, or chemotherapy - You are eligible for surgery and/or chemoradiotherapy - Your expected survival is more than 3 months - You can provide blood samples at multiple time points **You may NOT be eligible if...** - You are already in another clinical trial - You are pregnant or breastfeeding - You have severe mental illness - You are unable to follow the study protocol Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTAssess the risk of recurrence and the efficacy of medication

Evaluation of recurrence risk and medication efficacy through liquid biopsy


Locations(1)

The Third Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

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NCT06420427